Null Mutations of Group A Streptococcus Orphan Kinase RocA: Selection in Mouse Infection and Comparison with CovS Mutations in Alteration of In Vitro and In Vivo Protease SpeB Expression and Virulence

Group A Streptococcus (GAS) acquires mutations of the virulence regulator CovRS in human and mouse infections, and these mutations result in the upregulation of virulence genes and the downregulation of the protease SpeB. To identify in vivo mutants with novel phenotypes, GAS isolates from infected...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Feng, Wenchao, Minor, Dylan, Liu, Mengyao, Li, Jinquan, Ishaq, Suzanne L., Yeoman, Carl, Lei, Benfang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203639/
https://ncbi.nlm.nih.gov/pubmed/27795364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00790-16
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