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Benzoate- and Salicylate-Tolerant Strains of Escherichia coli K-12 Lose Antibiotic Resistance during Laboratory Evolution

Escherichia coli K-12 W3110 grows in the presence of membrane-permeant organic acids that can depress cytoplasmic pH and accumulate in the cytoplasm. We conducted experimental evolution by daily diluting cultures in increasing concentrations of benzoic acid (up to 20 mM) buffered at external pH 6.5,...

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書誌詳細
出版年:Appl Environ Microbiol
主要な著者: Creamer, Kaitlin E., Ditmars, Frederick S., Basting, Preston J., Kunka, Karina S., Hamdallah, Issam N., Bush, Sean P., Scott, Zachary, He, Amanda, Penix, Stephanie R., Gonzales, Alexandra S., Eder, Elizabeth K., Camperchioli, Dominic W., Berndt, Adama, Clark, Michelle W., Rouhier, Kerry A., Slonczewski, Joan L.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2016
主題:
Physiology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203621/
https://ncbi.nlm.nih.gov/pubmed/27793830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02736-16
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