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Development of live-attenuated arenavirus vaccines based on codon deoptimization of the viral glycoprotein

Several arenaviruses, chiefly Lassa (LASV) in West Africa, cause hemorrhagic fever (HF) disease in humans and pose important public health problems in their endemic regions. To date, there are no FDA-approved arenavirus vaccines and current anti-arenaviral therapy is limited to the use of ribavirin...

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Foilsithe in:Virology
Main Authors: Cheng, Benson Y.H., Nogales, Aitor, de la Torre, Juan Carlos, Martínez-Sobrido, Luis
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201438/
https://ncbi.nlm.nih.gov/pubmed/27855284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.11.001
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