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Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes

BACKGROUND: While screening for an inhibitor of the peptidyl prolyl cis/trans isomerase, Pin1, we came across a brown algae polyphenol that blocks the differentiation of fibroblasts into adipocytes. However, its effectiveness on the accumulation of fat in the body has never been studied. METHODOLOGY...

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Опубликовано в: :PLoS One
Главные авторы: Suzuki, Atsuko, Saeki, Toshiyuki, Ikuji, Hiroko, Uchida, Chiyoko, Uchida, Takafumi
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201290/
https://ncbi.nlm.nih.gov/pubmed/28036348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168830
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