Transient Activation of GABA(B) Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons

Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABA(A) and GABA(B) receptors. Although activation of GABA(A) receptors inhibits spike generation, the con...

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Udgivet i:PLoS One
Main Authors: Estep, Chad M., Galtieri, Daniel J., Zampese, Enrico, Goldberg, Joshua A., Brichta, Lars, Greengard, Paul, Surmeier, D. James
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201262/
https://ncbi.nlm.nih.gov/pubmed/28036359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169044
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