Transient Activation of GABA(B) Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons

Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABA(A) and GABA(B) receptors. Although activation of GABA(A) receptors inhibits spike generation, the con...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Estep, Chad M., Galtieri, Daniel J., Zampese, Enrico, Goldberg, Joshua A., Brichta, Lars, Greengard, Paul, Surmeier, D. James
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201262/
https://ncbi.nlm.nih.gov/pubmed/28036359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169044
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