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Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development

Secreted Dickkopf (Dkk) proteins are major Wnt pathway modulators during organ development. Dkk1 has been widely studied and acts as a general Wnt inhibitor. However, the molecular function of other Dkks remains largely unknown. Here, we show that Dkk4 selectively inhibits a subset of Wnts, but is f...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Sima, Jian, Piao, Yulan, Chen, Yaohui, Schlessinger, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201035/
https://ncbi.nlm.nih.gov/pubmed/27864382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.143909
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