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Exon- and contraction-dependent functions of titin in sarcomere assembly

Titin-truncating variants (TTNtvs) are the major cause of dilated cardiomyopathy (DCM); however, allelic heterogeneity (TTNtvs in different exons) results in variable phenotypes, and remains a major hurdle for disease diagnosis and therapy. Here, we generated a panel of ttn mutants in zebrafish. Fou...

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Dettagli Bibliografici
Pubblicato in:Development
Autori principali: Shih, Yu-Huan, Dvornikov, Alexey V., Zhu, Ping, Ma, Xiao, Kim, Maengjo, Ding, Yonghe, Xu, Xiaolei
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201027/
https://ncbi.nlm.nih.gov/pubmed/27836965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.139246
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