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Exon- and contraction-dependent functions of titin in sarcomere assembly
Titin-truncating variants (TTNtvs) are the major cause of dilated cardiomyopathy (DCM); however, allelic heterogeneity (TTNtvs in different exons) results in variable phenotypes, and remains a major hurdle for disease diagnosis and therapy. Here, we generated a panel of ttn mutants in zebrafish. Fou...
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| Veröffentlicht in: | Development |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Company of Biologists Ltd
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5201027/ https://ncbi.nlm.nih.gov/pubmed/27836965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.139246 |
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