Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age‐related declines in voluntary physical activity

KEY POINTS: Physical inactivity, which drastically increases with advancing age, is associated with numerous chronic diseases. The nucleus accumbens (the pleasure and reward ‘hub’ in the brain) influences wheel running behaviour in rodents. RNA‐sequencing and subsequent bioinformatics analysis led u...

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Vydáno v:J Physiol
Hlavní autoři: Ruegsegger, Gregory N., Toedebusch, Ryan G., Childs, Thomas E., Grigsby, Kolter B., Booth, Frank W.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Neuroscience ‐ behavioural/systems/cognitive
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199738/
https://ncbi.nlm.nih.gov/pubmed/27461471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272489
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