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Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age‐related declines in voluntary physical activity

KEY POINTS: Physical inactivity, which drastically increases with advancing age, is associated with numerous chronic diseases. The nucleus accumbens (the pleasure and reward ‘hub’ in the brain) influences wheel running behaviour in rodents. RNA‐sequencing and subsequent bioinformatics analysis led u...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Ruegsegger, Gregory N., Toedebusch, Ryan G., Childs, Thomas E., Grigsby, Kolter B., Booth, Frank W.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199738/
https://ncbi.nlm.nih.gov/pubmed/27461471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272489
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