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Role of Cl(−)–HCO(3) (−) exchanger AE3 in intracellular pH homeostasis in cultured murine hippocampal neurons, and in crosstalk to adjacent astrocytes
KEY POINTS: A polymorphism of human AE3 is associated with idiopathic generalized epilepsy. Knockout of AE3 in mice lowers the threshold for triggering epileptic seizures. The explanations for these effects are elusive. Comparisons of cells from wild‐type vs. AE3(–/–) mice show that AE3 (present in...
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| Publicado no: | J Physiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5199729/ https://ncbi.nlm.nih.gov/pubmed/27353306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272470 |
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