Targeting type I interferon–mediated activation restores immune function in chronic HIV infection

Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV infection, yet the mechanisms driving these processes are unclear. Chronic activation can be a driving force in immune exhaustion, and type I interferons (IFN-I) are emerging as critical components underlying on...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Zhen, Anjie, Rezek, Valerie, Youn, Cindy, Lam, Brianna, Chang, Nelson, Rick, Jonathan, Carrillo, Mayra, Martin, Heather, Kasparian, Saro, Syed, Philip, Rice, Nicholas, Brooks, David G., Kitchen, Scott G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199686/
https://ncbi.nlm.nih.gov/pubmed/27941243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89488
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