novoBreak: local assembly for breakpoint detection in cancer genomes

We present novoBreak, a novel genome-wide local assembly algorithm that discovers somatic and germline structural variation breakpoints in whole genome sequencing data. In the ICGC-TCGA DREAM 8.5 Somatic Mutation Calling Challenge and real cancer genome data analysis, novoBreak consistently outperfo...

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Bibliografske podrobnosti
izdano v:Nat Methods
Main Authors: Chong, Zechen, Ruan, Jue, Gao, Min, Zhou, Wanding, Chen, Tenghui, Fan, Xian, Ding, Li, Lee, Anna Y., Boutros, Paul, Chen, Junjie, Chen, Ken
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199621/
https://ncbi.nlm.nih.gov/pubmed/27892959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4084
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