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Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types

BACKGROUND: An important step towards personalizing cancer treatment is to integrate heterogeneous evidences to catalog mutational hotspots that are biologically and therapeutically relevant and thus represent where targeted therapy would likely be beneficial. However, existing methods do not suffic...

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Bibliografski detalji
Izdano u:BMC Genomics
Glavni autori: Chen, Tenghui, Wang, Zixing, Zhou, Wanding, Chong, Zechen, Meric-Bernstam, Funda, Mills, Gordon B., Chen, Ken
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928158/
https://ncbi.nlm.nih.gov/pubmed/27356755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2727-x
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