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Covalently circularized nanodiscs for studying membrane proteins and viral entry

We engineered covalently circularized nanodiscs (cNDs) with enhanced stability, defined diameter sizes and tunable shapes. Reconstitution into cNDs enhanced the quality of NMR spectra for both VDAC-1, a beta-barrel membrane protein, and the G protein-coupled receptor NTR1, an alpha-helical membrane...

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Foilsithe in:Nat Methods
Main Authors: Nasr, Mahmoud L., Baptista, Diego, Strauss, Mike, Sun, Zhen-Yu J., Grigoriu, Simina, Huser, Sonja, Plückthun, Andreas, Hagn, Franz, Walz, Thomas, Hogle, James M., Wagner, Gerhard
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199620/
https://ncbi.nlm.nih.gov/pubmed/27869813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4079
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