Microcephaly proteins Wdr62 and Aspm define a mother centriole complex regulating centriole biogenesis, apical complex and cell fate

Mutations in several genes encoding centrosomal proteins dramatically decrease the size of the human brain. We show that Aspm and Wdr62 interact genetically to control brain size, with mice lacking Wdr62, Aspm or both showing gene dose-related centriole duplication defects that parallel the severity...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Jayaraman, Divya, Kodani, Andrew, Gonzalez, Dilenny M., Mancias, Joseph D., Mochida, Ganeshwaran H., Vagnoni, Cristiana, Johnson, Jeffrey, Krogan, Nevan, Harper, J. Wade, Reiter, Jeremy F., Yu, Timothy W., Bae, Byoung-il, Walsh, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199216/
https://ncbi.nlm.nih.gov/pubmed/27974163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.09.056
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