Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WD...

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書目詳細資料
發表在:eLife
Main Authors: Kodani, Andrew, Yu, Timothy W, Johnson, Jeffrey R, Jayaraman, Divya, Johnson, Tasha L, Al-Gazali, Lihadh, Sztriha, Lāszló, Partlow, Jennifer N, Kim, Hanjun, Krup, Alexis L, Dammermann, Alexander, Krogan, Nevan J, Walsh, Christopher A, Reiter, Jeremy F
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2015
主題:
Cell Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574112/
https://ncbi.nlm.nih.gov/pubmed/26297806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07519
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