Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To explore this potential linkage, the STN was s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Atherton, Jeremy F, McIver, Eileen L, Mullen, Matthew RM, Wokosin, David L, Surmeier, D James, Bevan, Mark D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2016
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199195/
https://ncbi.nlm.nih.gov/pubmed/27995895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21616
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