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Model‐guided combinatorial optimization of complex synthetic gene networks
Constructing gene circuits that satisfy quantitative performance criteria has been a long‐standing challenge in synthetic biology. Here, we show a strategy for optimizing a complex three‐gene circuit, a novel proportional miRNA biosensor, using predictive modeling to initiate a search in the phase s...
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| Publicado en: | Mol Syst Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5199127/ https://ncbi.nlm.nih.gov/pubmed/28031353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20167265 |
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