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Model‐guided combinatorial optimization of complex synthetic gene networks

Constructing gene circuits that satisfy quantitative performance criteria has been a long‐standing challenge in synthetic biology. Here, we show a strategy for optimizing a complex three‐gene circuit, a novel proportional miRNA biosensor, using predictive modeling to initiate a search in the phase s...

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Bibliografske podrobnosti
izdano v:Mol Syst Biol
Main Authors: Schreiber, Joerg, Arter, Meret, Lapique, Nicolas, Haefliger, Benjamin, Benenson, Yaakov
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199127/
https://ncbi.nlm.nih.gov/pubmed/28031353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20167265
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