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Model‐guided combinatorial optimization of complex synthetic gene networks
Constructing gene circuits that satisfy quantitative performance criteria has been a long‐standing challenge in synthetic biology. Here, we show a strategy for optimizing a complex three‐gene circuit, a novel proportional miRNA biosensor, using predictive modeling to initiate a search in the phase s...
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| Vydáno v: | Mol Syst Biol |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5199127/ https://ncbi.nlm.nih.gov/pubmed/28031353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20167265 |
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