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Yeast GPCR signaling reflects the fraction of occupied receptors, not the number

According to receptor theory, the effect of a ligand depends on the amount of agonist–receptor complex. Therefore, changes in receptor abundance should have quantitative effects. However, the response to pheromone in Saccharomyces cerevisiae is robust (unaltered) to increases or reductions in the ab...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Bush, Alan, Vasen, Gustavo, Constantinou, Andreas, Dunayevich, Paula, Patop, Inés Lucía, Blaustein, Matías, Colman‐Lerner, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199120/
https://ncbi.nlm.nih.gov/pubmed/28034910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20166910
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