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Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets

Human platelets display a unique dual receptor system for responding to its primary endogenous activator, α-thrombin. Because of the lack of efficacious antagonists, the field has relied on synthetic peptides and pepducins to describe protease-activated receptor PAR1 and PAR4 signaling. The precise...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Duvernay, Matthew T., Temple, Kayla J., Maeng, Jae G., Blobaum, Anna L., Stauffer, Shaun R., Lindsley, Craig W., Hamm, Heidi E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198515/
https://ncbi.nlm.nih.gov/pubmed/27784794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.106666
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