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Inducible Expression of Claudin-1 in Glomerular Podocytes Generates Aberrant Tight Junctions and Proteinuria through Slit Diaphragm Destabilization

The tight junction (TJ) has a key role in regulating paracellular permeability to water and solutes in the kidney. However, the functional role of the TJ in the glomerular podocyte is unclear. In diabetic nephropathy, the gene expression of claudins, in particular claudin-1, is markedly upregulated...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Gong, Yongfeng, Sunq, Abby, Roth, Robyn A., Hou, Jianghui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198280/
https://ncbi.nlm.nih.gov/pubmed/27151920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015121324
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