MAP17 Is a Necessary Activator of Renal Na(+)/Glucose Cotransporter SGLT2

The renal proximal tubule reabsorbs 90% of the filtered glucose load through the Na(+)-coupled glucose transporter SGLT2, and specific inhibitors of SGLT2 are now available to patients with diabetes to increase urinary glucose excretion. Using expression cloning, we identified an accessory protein,...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Autores principales: Coady, Michael J., El Tarazi, Abdulah, Santer, René, Bissonnette, Pierre, Sasseville, Louis J., Calado, Joaquim, Lussier, Yoann, Dumayne, Christopher, Bichet, Daniel G., Lapointe, Jean-Yves
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2017
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198278/
https://ncbi.nlm.nih.gov/pubmed/27288013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015111282
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