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Adaptive evolution that requires multiple spontaneous mutations: mutations involving base substitutions.

A previous study has demonstrated that adaptive missense mutations occur in the trp operon of Escherichia coli. In this study it is shown that, under conditions of intense selection, a strain carrying missense mutations in both trpA and trpB reverts to Trp+ 10(8) times more frequently than would be...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Autor principal: Hall, B G
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51982/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2062865/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.13.5882
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