Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas

In humans suffering from pulmonary disease and a mouse model, transient receptor potential vanilloid 4 (TRPV4) channel activation contributes to fibrosis. As a corneal alkali burn induces the same response, we determined if such an effect is also attributable to TRPV4 activation in mice. Accordingly...

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Veröffentlicht in:PLoS One
Hauptverfasser: Okada, Yuka, Shirai, Kumi, Miyajima, Masayasu, Reinach, Peter S., Yamanaka, Osamu, Sumioka, Takayoshi, Kokado, Masahide, Tomoyose, Katsuo, Saika, Shizuya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193391/
https://ncbi.nlm.nih.gov/pubmed/28030558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167200
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