Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid generated through sphingosine kinase1 (SPK1)-mediated phosphorylation of sphingosine. We show here that injury-induced S1P upregulation increases corneal neovascularization through stimulating S1PR3, a cognate receptor. since this response wa...

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Bibliografske podrobnosti
izdano v:Lab Invest
Main Authors: Yasuda, Shingo, Sumioka, Takayoshi, Iwanishi, Hiroki, Okada, Yuka, Miyajima, Masayasu, Ichikawa, Kana, Reinach, Peter S., Saika, Shizuya
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group US 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815507/
https://ncbi.nlm.nih.gov/pubmed/33199821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-020-00505-1
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