ATXN2 is a modifier of phenotype in ALS patients of Sardinian ancestry

Intermediate-length CAG expansions (encoding 27–33 glutamines, polyQ) of the Ataxin2 (ATXN2) gene represent a risk factor for amyotrophic lateral sclerosis (ALS). Recently, it has been proposed that ≥31 CAG expansions may influence ALS phenotype. We assessed whether ATXN2 intermediate-length polyQ e...

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Bibliografske podrobnosti
izdano v:Neurobiol Aging
Main Authors: Borghero, Giuseppe, Pugliatti, Maura, Marrosu, Francesco, Marrosu, Maria Giovanna, Murru, Maria Rita, Floris, Gianluca, Cannas, Antonino, Parish, Leslie D., Cau, Tea B., Loi, Daniela, Ticca, Anna, Traccis, Sebastiano, Manera, Umberto, Canosa, Antonio, Moglia, Cristina, Calvo, Andrea, Barberis, Marco, Brunetti, Maura, Renton, Alan E., Nalls, Mike A., Traynor, Bryan J., Restagno, Gabriella, Chiò, Adriano
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193218/
https://ncbi.nlm.nih.gov/pubmed/26208502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.06.013
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