SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization

We currently have limited knowledge of the involvement of long non-coding RNAs (lncRNAs) in normal cellular processes and pathologies. Here, we identify and characterize SNHG5 as a stable cytoplasmic lncRNA with up-regulated expression in colorectal cancer. Depletion of SNHG5 induces cell cycle arre...

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Udgivet i:Nat Commun
Main Authors: Damas, Nkerorema Djodji, Marcatti, Michela, Côme, Christophe, Christensen, Lise Lotte, Nielsen, Morten Muhlig, Baumgartner, Roland, Gylling, Helene Maria, Maglieri, Giulia, Rundsten, Carsten Friis, Seemann, Stefan E., Rapin, Nicolas, Thézenas, Simon, Vang, Søren, Ørntoft, Torben, Andersen, Claus Lindbjerg, Pedersen, Jakob Skou, Lund, Anders H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192221/
https://ncbi.nlm.nih.gov/pubmed/28004750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13875
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