Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

Hypoxia is a major driving force of cancer invasion and metastasis. Here we show that death domain-associated protein (Daxx) acts to negatively regulate hypoxia-induced cell dissemination and invasion by inhibiting the HIF-1α/HDAC1/Slug pathway. Daxx directly binds to the DNA-binding domain of Slug,...

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Publicat a:Nat Commun
Autors principals: Lin, Ching-Wen, Wang, Lu-Kai, Wang, Shu-Ping, Chang, Yi-Liang, Wu, Yi-Ying, Chen, Hsuan-Yu, Hsiao, Tzu-Hung, Lai, Wei-Yun, Lu, Hsuan-Hsuan, Chang, Ya-Hsuan, Yang, Shuenn-Chen, Lin, Ming-Wei, Chen, Chi-Yuan, Hong, Tse-Ming, Yang, Pan-Chyr
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192219/
https://ncbi.nlm.nih.gov/pubmed/28004751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13867
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