Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to delayed activation of mucosal dendritic cells (DCs), and subsequent delay in antigen present...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Griffiths, Kristin L., Ahmed, Mushtaq, Das, Shibali, Gopal, Radha, Horne, William, Connell, Terry D., Moynihan, Kelly D., Kolls, Jay K., Irvine, Darrell J., Artyomov, Maxim N., Rangel-Moreno, Javier, Khader, Shabaana A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192216/
https://ncbi.nlm.nih.gov/pubmed/28004802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13894
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