Pharmacodynamics of Voriconazole against Wild-Type and Azole-Resistant Aspergillus flavus Isolates in a Nonneutropenic Murine Model of Disseminated Aspergillosis

Invasive aspergillosis (IA) due to Aspergillus flavus is associated with high mortality. Although voriconazole (VRC) is widely recommended as the first-line treatment for IA, emergence of azole resistance in Aspergillus spp. is translating to treatment failure. We evaluated the efficacy of voriconaz...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Rudramurthy, Shivaprakash M., Seyedmousavi, Seyedmojtaba, Dhaliwal, Manpreet, Chakrabarti, Arunaloke, Meis, Jacques F., Mouton, Johan W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192161/
https://ncbi.nlm.nih.gov/pubmed/27821453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01491-16
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