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CTX-M-190, a Novel β-Lactamase Resistant to Tazobactam and Sulbactam, Identified in an Escherichia coli Clinical Isolate

A novel β-lactamase, CTX-M-190, derived from CTX-M-55 by a single substitution of Ser for Thr at position 133 (Ser133Thr), was identified in a natural Escherichia coli clinical isolate. CTX-M-190 exhibited potent hydrolytic activity against cefotaxime, with a k(cat)/K(m) ratio of 14.5 μM(−1) s(−1),...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Shen, Zhen, Ding, Baixing, Bi, Yingmin, Wu, Shi, Xu, Su, Xu, Xiaogang, Guo, Qinglan, Wang, Minggui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192109/
https://ncbi.nlm.nih.gov/pubmed/27821452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01848-16
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