In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam

Here, we report a novel narrow-spectrum β-lactamase CTX-M-215 identified in an Escherichia coli clinical isolate in China and conferring high-level resistance to mecillinam but not to cefotaxime. CTX-M-215 differed from CTX-M-125, a CTX-M extended-spectrum β-lactamase (ESBL), by an N132D substitutio...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Yin, Mengyun, Hu, Guoping, Shen, Zhen, Fang, Chengli, Zhang, Xuefei, Li, Dan, Doi, Yohei, Zhang, Yu, Wang, Minggui, Guo, Qinglan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577136/
https://ncbi.nlm.nih.gov/pubmed/32868328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00562-20
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