Aging is associated with an expansion of CD49f(hi) mammary stem cells that show a decline in function and increased transformation potential

Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated f...

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Enregistré dans:
Détails bibliographiques
Publié dans:Aging (Albany NY)
Auteurs principaux: Dong, Qiaoxiang, Gao, Hui, Shi, Yuanshuo, Zhang, Fuchuang, Gu, Xiang, Wu, Anqi, Wang, Danhan, Chen, Yuanhong, Bandyopadhyay, Abhik, Yeh, I-Tien, Daniel, Benjamin J., Chen, Yidong, Zou, Yi, Rebel, Vivienne L., Walter, Christi A., Lu, Jianxin, Huang, Changjiang, Sun, Lu-Zhe
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5191868/
https://ncbi.nlm.nih.gov/pubmed/27852980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101082
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