Aging is associated with an expansion of CD49f(hi) mammary stem cells that show a decline in function and increased transformation potential

Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated f...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Dong, Qiaoxiang, Gao, Hui, Shi, Yuanshuo, Zhang, Fuchuang, Gu, Xiang, Wu, Anqi, Wang, Danhan, Chen, Yuanhong, Bandyopadhyay, Abhik, Yeh, I-Tien, Daniel, Benjamin J., Chen, Yidong, Zou, Yi, Rebel, Vivienne L., Walter, Christi A., Lu, Jianxin, Huang, Changjiang, Sun, Lu-Zhe
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5191868/
https://ncbi.nlm.nih.gov/pubmed/27852980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101082
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