Copper inhibits the protease from human immunodeficiency virus 1 by both cysteine-dependent and cysteine-independent mechanisms.
The protease of the human immunodeficiency virus is essential for replication of the virus, and the enzyme is therefore an attractive target for antiviral action. We have found that the viral protease is inhibited by approximately stoichiometric concentrations of copper or mercury ions. Inactivation...
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| Опубліковано в:: | Proc Natl Acad Sci U S A |
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| Автори: | , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
National Academy of Sciences
1991
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2062837/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.13.5552 |
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