Insufficient Folding of Type IV Collagen and Formation of Abnormal Basement Membrane-like Structure in Embryoid Bodies Derived from Hsp47-Null Embryonic Stem Cells

Hsp47 is a molecular chaperone that specifically recognizes procollagen in the endoplasmic reticulum. Hsp47-null mouse embryos produce immature type I collagen and form discontinuous basement membranes. We established Hsp47(-/-) embryonic stem cell lines and examined formation of basement membrane a...

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Autores principales: Matsuoka, Yasuhiro, Kubota, Hiroshi, Adachi, Eijiro, Nagai, Naoko, Marutani, Toshihiro, Hosokawa, Nobuko, Nagata, Kazuhiro
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2004
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC519141/
https://ncbi.nlm.nih.gov/pubmed/15282337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-01-0050
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