Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones

Osteosarcoma (OS) is the most common pediatric bone tumor and is associated with the emergence of pulmonary metastasis. Unfortunately, the mechanistic basis for metastasis remains unclear. Tumor-derived extracellular vesicles (EVs) have been shown to play critical roles in cell-to-cell communication...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Macklin, Rebecca, Wang, Haolu, Loo, Dorothy, Martin, Sally, Cumming, Andrew, Cai, Na, Lane, Rebecca, Ponce, Natalia Saenz, Topkas, Eleni, Inder, Kerry, Saunders, Nicholas A, Endo-Munoz, Liliana
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190045/
https://ncbi.nlm.nih.gov/pubmed/27259278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9781
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