Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis

Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10–20% long-term survival. The factors and pathways regulating these processes remain unclear, yet their identification is crucial in order to find new therapeutic targets. In this study we used a multi-omic...

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Udgivet i:PLoS One
Main Authors: Endo-Munoz, Liliana, Cai, Na, Cumming, Andrew, Macklin, Rebecca, Merida de Long, Lilia, Topkas, Eleni, Mukhopadhyay, Pamela, Hill, Michelle, Saunders, Nicholas A
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552671/
https://ncbi.nlm.nih.gov/pubmed/26317203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133592
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