Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma

Resistance to epidermal growth factor receptor (EGFR)-targeted therapy is insufficiently understood in head and neck squamous cell carcinoma (HNSCC), entailing the lack of predictive biomarkers. Here, we studied resistance-mediating EGFR ectodomain and activating RAS mutations by next-generation seq...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Braig, Friederike, Voigtlaender, Minna, Schieferdecker, Aneta, Busch, Chia-Jung, Laban, Simon, Grob, Tobias, Kriegs, Malte, Knecht, Rainald, Bokemeyer, Carsten, Binder, Mascha
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190002/
https://ncbi.nlm.nih.gov/pubmed/27119512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8943
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