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Intracellular Zn(II) Intoxication Leads to Dysregulation of the PerR Regulon Resulting in Heme Toxicity in Bacillus subtilis

Transition metal ions (Zn(II), Cu(II)/(I), Fe(III)/(II), Mn(II)) are essential for life and participate in a wide range of biological functions. Cellular Zn(II) levels must be high enough to ensure that it can perform its essential roles. Yet, since Zn(II) binds to ligands with high avidity, excess...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Chandrangsu, Pete, Helmann, John D.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5189952/
https://ncbi.nlm.nih.gov/pubmed/27935957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006515
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