Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression.
Protooncogene c-fos is induced by activation of adenylate cyclase through the major cAMP-responsive element (CRE) centered at position -60 of the promoter. cAMP induction is followed by a rapid decrease in transcriptional rate, reminiscent of down-regulation after serum stimulation. Fos protein is k...
में बचाया:
| में प्रकाशित: | Proc Natl Acad Sci U S A |
|---|---|
| मुख्य लेखकों: | , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
National Academy of Sciences
1991
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51890/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1647033/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.12.5448 |
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