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Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression.

Protooncogene c-fos is induced by activation of adenylate cyclase through the major cAMP-responsive element (CRE) centered at position -60 of the promoter. cAMP induction is followed by a rapid decrease in transcriptional rate, reminiscent of down-regulation after serum stimulation. Fos protein is k...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Foulkes, N S, Laoide, B M, Schlotter, F, Sassone-Corsi, P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1991
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC51890/
https://ncbi.nlm.nih.gov/pubmed/1647033
Tagiau: Ychwanegu Tag
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