Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination

Systemic lupus erythematosus (SLE) is a multigenic autoimmune disease, and the major histocompatibility complex (MHC) class II polymorphism serves as a key genetic element. In SLE-prone (NZB × NZW)F(1) mice, the MHC H-2(d/z) heterozygosity (H-2(d) of NZB and H-2(z) of NZW) has a strong impact on dis...

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Autors principals: Zhang, Danqing, Fujio, Keishi, Jiang, Yi, Zhao, Jingyuan, Tada, Norihiro, Sudo, Katsuko, Tsurui, Hiromichi, Nakamura, Kazuhiro, Yamamoto, Kazuhiko, Nishimura, Hiroyuki, Shira, Toshikazu, Hirose, Sachiko
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC518842/
https://ncbi.nlm.nih.gov/pubmed/15361580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405807101
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