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The Emergence of the Dose–Response Concept in Biology and Medicine

A historical assessment of the origin of the dose–response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose–response models emerged in the late 19th an...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Autor principal: Calabrese, Edward J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187834/
https://ncbi.nlm.nih.gov/pubmed/27929392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17122034
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