miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling

Invariant natural killer T cells (iNKT) cells are T lymphocytes displaying innate effector functions, acquired through a distinct thymic developmental program regulated by microRNAs (miRNAs). Deleting miRNAs by Dicer ablation (Dicer KO) in thymocytes selectively impairs iNKT cell survival and functi...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fedeli, Maya, Riba, Michela, Garcia Manteiga, Jose Manuel, Tian, Lei, Viganò, Valentina, Rossetti, Grazisa, Pagani, Massimiliano, Xiao, Changchun, Liston, Adrian, Stupka, Elia, Cittaro, Davide, Abrignani, Sergio, Provero, Paolo, Dellabona, Paolo, Casorati, Giulia
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187732/
https://ncbi.nlm.nih.gov/pubmed/27930306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612024114
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