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Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells

Vascular smooth muscle cell (VSMC) motility is essential during both physiological and pathological vessel remodeling. Although ageing has emerged as a major risk factor in the development of cardiovascular disease, our understanding of the impact of ageing on VSMC motility remains limited. Prelamin...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Porter, Lauren J., Holt, Mark R., Soong, Daniel, Shanahan, Catherine M., Warren, Derek T.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187525/
https://ncbi.nlm.nih.gov/pubmed/27854297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells5040041
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