Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity

Smooth muscle alpha-actin (SMA) is a marker for the contractile, non-proliferative phenotype of adult smooth muscle cells (SMCs). Upon arterial injury, expression of SMA and other structural proteins decreases and SMCs acquire a pro-migratory and proliferative phenotype. To what extent SMA regulates...

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Pubblicato in:PLoS One
Autori principali: Chen, Lihua, DeWispelaere, Allison, Dastvan, Frank, Osborne, William R. A., Blechner, Christine, Windhorst, Sabine, Daum, Guenter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866761/
https://ncbi.nlm.nih.gov/pubmed/27176050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155726
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