MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

The transforming growth factor β (TGFβ) pathway plays critical roles during cancer cell epithelial-mesenchymal transition (EMT) and metastasis. SMAD7 is both a transcriptional target and a negative regulator of TGFβ signalling, thus mediating a negative feedback loop that may potentially restrain TG...

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Publicat a:Nat Commun
Autors principals: Yu, Jingyi, Lei, Rong, Zhuang, Xueqian, Li, Xiaoxun, Li, Gang, Lev, Sima, Segura, Miguel F., Zhang, Xue, Hu, Guohong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187443/
https://ncbi.nlm.nih.gov/pubmed/27996004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13884
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